Researchers from the University of Western Ontario are currently studying nobiletin, a molecule in tangerines and sweet oranges that has shown to reduce obesity in mice and reverse the related side effects. Why the molecule has the effect it does is still unknown. Take a moment to learn what the study authors do know as part of your commitment to diet changes with Phentermine 37.5mg. The research was published in the Journal of Lipid Research.
Lowers Blood Fat & Insulin Resistance
Mice given nobiletin were leaner and had less blood fat as well as reduced insulin resistance compared to rodents fed a high-cholesterol, high-fat diet.
“We went on to show that we can also intervene with nobiletin,” said Murray Huff, PhD, a Professor at Western’s Schulich School of Medicine & Dentistry. Dr. Huff has been studying nobiletin’s effects for over 10 years. “We’ve shown that in mice that already have all the negative symptoms of obesity, we can use nobelitin to reverse those symptoms, and even start to regress plaque build-up in the arteries, known as atherosclerosis.”
Pathways That Regulate Fat Activity?
While Huff and his team are still uncertain why nobiletin works against obesity, current theories include the molecule working on a pathway that oversees fat activities in the body. The pathway is called AMP Kinase and helps the body burn fat as energy while also blocking fat production. Yet the effects of the molecule were the same in mice that had this pathway removed.
“This result told us that nobiletin is not acting on AMP Kinase, and is bypassing this major regulator of how fat is used in the body,” said Huff. “What it still leaves us with is the question — how is nobiletin doing this?”
Human Studies
Huff says the next step is to test the effects of nobiletin on humans.
“Obesity and its resulting metabolic syndromes are a huge burden to our health care system, and we have very few interventions that have been shown to work effectively,” said Huff. “We need to continue this emphasis on the discovery of new therapeutics.”
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